Joining Nero's anti-demon crusade is Dante, veteran demon-slayer and son of the Dark Knight Sparda, and a new, goth-styled character called V, who summons weaponized nightmares and has a thing for the poetry of William Blake. In the main plot for Devil May Cry 5, the protagonist is nominally Nero, a demon hunter who's trying to save Redgrave city from a demonic invasion and a world-consuming tree called the Qliphoth, wielding a big sword, a giant revolver, and a variety of cybernetic limb weapons called Devil Breakers, prosthetic limb replacements for the demon charm chopped off by the demon antagonist called Urizen.
With this update of DMC 5, developers at Capcom also have the opportunity to also introduce the two women protagonist of the Devil May Cry series, demon hunters Lady and Trish, as playable characters in the main campaign, or their own DLC, a development that was foreshadowed in the ending cinematic cutscene of the original Devil May Cry 5. The upcoming hack'n'slash brawler Devil May Cry 5 Special Edition, set to be released on the Playstation 5, will introduce new gameplay features, improved graphics, and Vergil, the signature anti-villain of the Devil May Cry series, as a playable character in the campaign and the Bloody Palace survival mode.